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J Infect Dis. 2002 Apr 15;185(8):1155-64. Epub 2002 Apr 1.

Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites.

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1
Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20850, USA. stephen.hoffman@celera.com

Abstract

During 1989-1999, 11 volunteers were immunized by the bites of 1001-2927 irradiated mosquitoes harboring infectious sporozoites of Plasmodium falciparum (Pf) strain NF54 or clone 3D7/NF54. Ten volunteers were first challenged by the bites of Pf-infected mosquitoes 2-9 weeks after the last immunization, and all were protected. A volunteer challenged 10 weeks after the last immunization was not protected. Five previously protected volunteers were rechallenged 23-42 weeks after a secondary immunization, and 4 were protected. Two volunteers were protected when rechallenged with a heterologous Pf strain (7G8). In total, there was protection in 24 of 26 challenges. These results expand published findings demonstrating that immunization by exposure to thousands of mosquitoes carrying radiation-attenuated Pf sporozoites is safe and well tolerated and elicits strain-transcendent protective immunity that persists for at least 42 weeks.

PMID:
11930326
DOI:
10.1086/339409
[Indexed for MEDLINE]
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