Differences in Candida albicans adhesion to intact and denatured type I collagen in vitro

Oral Microbiol Immunol. 2002 Apr;17(2):129-31. doi: 10.1046/j.0902-0055.2001.00094.x.

Abstract

An inhibition assay of Candida albicans adhesion to gelatin-immobilized membranes was compared with that to intact type I collagen-immobilized membranes using an arginine-glycine-aspartic acid (RGD) containing peptide. As compared with a protein-free membrane, gelatin and collagen significantly enhanced the adherence of C. albicans. The adhesion of the yeast to gelatin was significantly inhibited by the RGD peptides, but not by arginine-glycine-glutamic acid (RGE) peptides. In contrast, attachment to collagen was not inhibited by RGD peptides. These results suggest that the RGD sequence of gelatin and the integrin-like proteins of yeasts may be involved in adherence.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesiveness
  • Candida albicans / drug effects
  • Candida albicans / physiology*
  • Collagen Type I / chemistry*
  • Gelatin / chemistry
  • Humans
  • Integrins / physiology
  • Membranes, Artificial
  • Oligopeptides / pharmacology
  • Receptors, Immunologic / physiology
  • Surface Properties

Substances

  • Collagen Type I
  • Integrins
  • Membranes, Artificial
  • Oligopeptides
  • Receptors, Immunologic
  • arginyl-glycyl-glutamic acid
  • arginyl-glycyl-aspartic acid
  • Gelatin