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Trends Immunol. 2002 Feb;23(2):96-101.

Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling.

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  • 1Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA.


The paradigm that emerged from studies during the past decade established a central role for Jak-Stat (signal transducer and activator of transcription) signaling pathways in promoting the diverse cellular responses induced by interferon gamma (IFN-gamma). However, recent studies have shown that the IFN-gamma receptor activates additional signaling pathways and can regulate gene expression by Stat1-independent pathways. The diversity of gene-expression patterns mediated by Stat1-dependent and -independent mechanisms and the balance between these two pathways play an important role in the biological response to IFN-gamma.

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