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Fiziol Zh. 2002;48(1):98-101.

[Effects of T-type calcium channel blockers on spontaneous meiotic maturation of mouse ovarian oocytes in vitro].

[Article in Ukrainian]

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A.A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev.


We studied the effects of blockers of the T-type Ca2+ channels on resumption of meiosis and spontaneous meiotic maturation of murine ovarial oocytes in vitro. We found that the efficiency of suppression of oocyte maturation by blockers of the Ca2+ channels increases in the following succession: amiloride hydrochloride, mebifradil, NiCl2. It is supposed that there is a possibility to use blockers of the T-type Ca2+ channels for creation of new combined intrauterine contraceptives.

[Indexed for MEDLINE]

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