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Arch Otolaryngol Head Neck Surg. 2002 Apr;128(4):401-6.

The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract: friend or foe?

Author information

1
Department of Otolaryngology and Communication Disorders, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA. reza.rahbar@tch.harvard.edu

Abstract

OBJECTIVE:

To evaluate the role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract.

DESIGN:

Prospective study; institutional review board-approved clinical trial.

SETTING:

Tertiary care pediatric medical center.

PATIENTS:

Fifteen patients; choanal atresia in 5 patients, airway stenosis in 8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis in 1 patient.

OUTCOME:

The efficacy and safety of mitomycin in the prevention of scar formation.

INTERVENTION:

All patients underwent surgical repair of the stenotic area, followed by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes.

RESULTS:

Ten patients (67%) showed major improvement, 4 patients (27%) showed minor improvement, and 1 patient (7%) showed no improvement.

CONCLUSION:

Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.

PMID:
11926915
[Indexed for MEDLINE]

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