Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases

Inflamm Res. 2002 Feb;51(2):112-4. doi: 10.1007/BF02684014.

Authors

C S Stevenson¹, E A Capper, A K Roshak, B Marquez, K Grace, W H Gerwick, R S Jacobs, L A Marshall

Affiliation

¹ University of California Santa Barbara, Department of Ecology, Evolution, and Marine Biology, 93106, USA. Christopher.S.Stevenson@gsk.com

PMID: 11926312
DOI: 10.1007/BF02684014

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Cycle Proteins
Cell Division / drug effects
Cyanobacteria / chemistry
Endothelium, Vascular / cytology
Enzyme Inhibitors / pharmacology*
Humans
Indoles / pharmacology*
Indoles / therapeutic use
Inflammation / drug therapy
Inflammation / enzymology*
Inflammation / pathology*
Isoenzymes / antagonists & inhibitors
Male
Mice
Phenols / pharmacology*
Phenols / therapeutic use
Pigments, Biological
Polo-Like Kinase 1
Protein Kinase C / antagonists & inhibitors
Protein Kinase C beta
Protein Kinase Inhibitors*
Protein Kinases / metabolism
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins
Recombinant Proteins
Umbilical Veins

Substances

Cell Cycle Proteins
Enzyme Inhibitors
Indoles
Isoenzymes
Phenols
Pigments, Biological
Protein Kinase Inhibitors
Proto-Oncogene Proteins
Recombinant Proteins
scytonemin
Protein Kinases
Protein Serine-Threonine Kinases
Protein Kinase C
Protein Kinase C beta