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Hum Cell. 2001 Dec;14(4):257-60.

[Mechanisms of drug resistance and reversal of the resistance].

[Article in Japanese]

Author information

1
Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. akiyamas@m3.kufm.kagoshima-u.ac.jp

Abstract

The mechanisms for the resistance to anticancer agents have been vigorously studied and many factors that are involved in the resistance were found. Among the members of ABC transporter superfamily, P-glycoprotein, MRP1-5 and BCRP are involved in the drug resistance. LRP, identified as the major vault protein, is also related to drug resistance.

PMID:
11925925
[Indexed for MEDLINE]
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