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Br J Psychiatry. 2002 Apr;180:331-8.

Amygdala volume in schizophrenia: post-mortem study and review of magnetic resonance imaging findings.

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  • 1University of Oxford, UK. steven.chance@clneuro.ox.ac.uk

Abstract

BACKGROUND:

Claims that schizophrenia is a disease of the limbic system have been strengthened by meta-analyses of magnetic resonance imaging (MRI) studies finding reduced hippocampus and amygdala volumes. Some post-mortem studies do not find these abnormalities.

AIMS:

To assess the volume of the amygdala in a series of brains post-mortem.

METHOD:

Amygdala volume was estimated using point-counting in both hemispheres of the brains of 10 male and 8 female patients with schizophrenia, and a comparison group of 9 males and 9 females.

RESULTS:

No significant reduction of amygdala volume was found.

CONCLUSIONS:

Significant volume reduction of the amygdala is not a consistent feature of schizophrenia; findings from early MRI studies using coarse delineation methods may introduce bias to subsequent meta-analyses.

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PMID:
11925356
[PubMed - indexed for MEDLINE]
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