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Invest Radiol. 2002 Apr;37(4):193-8.

Magnetic resonance imaging of nude mice with heterotransplanted high-grade squamous cell carcinomas: use of a low-loaded, covalently bound Gd-Hsa conjugate as contrast agent with high tumor affinity.

Author information

1
Department of Oncological Diagnostics and Therapy, University of Essen, Germany. F.Kiessling@dkfz.de

Abstract

RATIONALE:

Malignant tumors often show an increased uptake and metabolism of plasma proteins, especially albumin.

OBJECTIVES:

Determine whether the accumulation of low loaded Gd-albumin improves visualization of malignant tumors by MRI.

METHODS:

Twelve nude mice with heterotransplanted squamous cell carcinomas were studied. The signal intensity of tumor, blood, liver, kidney and muscle tissue was studied in MR images after application of Gd-albumin during a period of 144 hours. MRI results were histologically correlated after simultaneously injection of Gd- and fluorescein-labeled albumins in 9 nude mice.

RESULTS:

Although liver and kidney had a maximum increase in signal intensity within 30 minutes, tumors showed a delayed 51% increase in the 24 hours after application. Histologic and fluorescence evaluation demonstrated albumin localization in tumors predominantly in stroma and necroses.

CONCLUSIONS:

Gd-albumin is efficiently accumulated in SCC transplants. MRI with low loaded Gd-albumin may offer relevant opportunities for recognizing tumors sensitive to a therapy with cyostic drug-labeled albumins.

PMID:
11923641
[Indexed for MEDLINE]

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