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J Clin Microbiol. 2002 Apr;40(4):1546-8.

Production of BRO beta-lactamases and resistance to complement in European Moraxella catarrhalis isolates.

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1
Institute for Medical Microbiology and Virology, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany. schmitfj@uni-duesseldorf.de

Abstract

Of the 419 Moraxella catarrhalis isolates collected during the 1997-1999 European SENTRY surveillance study, 385 (92%) were beta-lactamase positive. Twenty-two (5.7%) produced BRO-2 beta-lactamase. Twenty-one new mutations were found in the putative promoter region of the bro genes. Nineteen percent of all isolates tested were complement sensitive. Resistance to beta-lactams is not linked to the phylogenetic lineages associated with susceptibility to complement.

PMID:
11923393
PMCID:
PMC140350
[Indexed for MEDLINE]
Free PMC Article
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