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Adv Drug Deliv Rev. 2002 Mar 31;54(3):273-89.

Prediction of intestinal permeability.

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1
Accelrys Inc., ADMET R&D, CN 5350, Princeton, NJ 08543-5350, USA. bill_egan@vrtx.com

Abstract

This review focuses on computational methods for the prediction of passive intestinal permeability. Existing computational models are surveyed and assessed in terms of descriptors, model type/complexity, speed of computation, predictive performance, and interpretability. Challenges to the successful computational prediction of intestinal permeability, i.e. data quantity, measurement imprecision, confounding factors such as solubility, metabolism, or active efflux, and the need for robust statistical methods, are also discussed.

PMID:
11922948
[Indexed for MEDLINE]
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