Send to

Choose Destination
Zhonghua Yi Xue Za Zhi (Taipei). 2001 Dec;64(12):721-4.

Rectal administration of misoprostol for the management of retained placenta--a preliminary report.

Author information

Department of Obstetrics and Gynecology, Chung Shan Hospital, Taipei, Taiwan, ROC.



Retained placenta is one of the serious complications of childbirth, and misoprostol is known to be a potent uterotonic agent. Therefore, we proposed that rectal misoprostol also may facilitate placental separation in women with retained placenta by its ability to increase uterine contractility.


The placenta was diagnosed as retained if it was not expelled within 40 minutes after vaginal birth. Then, 800 microg of misoprostol was inserted rectally and the patient observed thereafter.


A total of 18 parturients who had retention of the placenta were studied; all the placentas were spontaneously expelled within 35 minutes. The side effects involved included nausea 17%, vomiting 11%, diarrhea 22%, shivering 33%, and pelvic cramping pain 44%. All these discomforts resolved within 24 hours.


Our study demonstrated that misoprostol per rectum is a safe and effective technique and may be a useful alternative to manual removal of retained placentas.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center