Format

Send to

Choose Destination
See comment in PubMed Commons below
Microsc Res Tech. 2002 Apr 1;57(1):55-9.

Multiple roles of adrenomedullin revealed by animal models.

Author information

1
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA.

Abstract

The newly identified adrenomedullin (AM) gene codes for a potent, highly conserved vasodilator that is expressed in many tissues. Many biological functions have been ascribed to AM based on its broad expression pattern and numerous in vitro studies, and it is currently viewed as a multifunctional peptide hormone. Recent advances in gene manipulation have permitted the development of experimental animal systems to help distinguish between gene causes and effects in the context of otherwise normal physiology, and so the normal biological function of the AM gene can be studied within the intact physiological milieu of a whole animal. In this review article, we summarize the recent findings from three different types of genetic experiments involving the AM gene.

PMID:
11921356
DOI:
10.1002/jemt.10046
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center