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Dev Dyn. 2002 Apr;223(4):427-58.

Development of the zebrafish inner ear.

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1
Centre for Developmental Genetics, University of Sheffield School of Medicine and Biomedical Science, Firth Court, Western Bank, Sheffield, United Kingdom. t.whitfield@sheffield.ac.uk

Abstract

Recent years have seen a renaissance of investigation into the mechanisms of inner ear development. Genetic analysis of zebrafish has contributed significantly to this endeavour, with several dramatic advances reported over the past year or two. Here, we review the major findings from recent work in zebrafish. Several cellular and molecular mechanisms have been elucidated, including the signaling pathways controlling induction of the otic placode, morphogenesis and patterning of the otic vesicle, and elaboration of functional attributes of inner ear.

PMID:
11921334
DOI:
10.1002/dvdy.10073
[Indexed for MEDLINE]
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