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J Med Virol. 2002 May;67(1):88-91.

Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy.

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Centre de Recherche en Infectiologie of the Centre Hospitalier Universitaire de Québec (Pavillon CHUL), and Universiteé Laval, Québec, Canada.


Sequential herpes simplex virus (HSV) isolates from AIDS patients receiving foscarnet therapy were evaluated for susceptibility to adefovir. Foscarnet-resistant isolates with DNA polymerase mutations in regions II, VI, and between I and VII were also associated with an important decrease in susceptibility to adefovir (mean IC50 increase: 4.6-fold compared to pre-foscarnet or wild-type isolates) suggesting that adefovir-resistant HSV could be selected in vivo by foscarnet therapy.

[Indexed for MEDLINE]

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