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Nucleic Acids Res. 2002 Apr 1;30(7):1558-62.

Multiple thiol-anchor capped DNA-gold nanoparticle conjugates.

Author information

1
Northwestern University, Department of Chemistry and Institute for Nanotechnology, 2145 Sheridan Road, Evanston, IL 60208, USA.

Abstract

We report the synthesis of a novel trithiol-capped oligodeoxyribonucleotide and gold nanoparticle conjugates prepared from it. These DNA-gold nanoparticle conjugates exhibit substantially higher stability than analogs prepared from monothiol and cyclic disulfide-capped oligodeoxyribonucleotides, but comparable hybridization properties. A quantitative analysis of their stability under a range of conditions is provided. Significantly, this novel trithiol oligodeoxyribonucleotide can be used to stabilize particles >30 nm in diameter, which are essential for many diagnostic applications.

PMID:
11917016
PMCID:
PMC101851
DOI:
10.1093/nar/30.7.1558
[Indexed for MEDLINE]
Free PMC Article

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