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Infect Dis Obstet Gynecol. 2001;9(4):239-44.

The inhibitory effect of clindamycin on Lactobacillus in vitro.

Author information

1
Department of Obstetrics and Gynecology, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL, USA.

Abstract

OBJECTIVE:

To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobocillus spp.

METHODS:

Concentrations of clindamycin ranging from 1.95-20,000 microg/ml were studied for their effect on the growth of six strains of Lactobacillus.

RESULTS:

Clindamycin concentrations between 1.95-31.25 microg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 microg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1,000 microg/ml.

CONCLUSION:

High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus.

PMID:
11916182
PMCID:
PMC1784659
DOI:
10.1155/S1064744901000394
[Indexed for MEDLINE]
Free PMC Article

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