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Nat Neurosci. 2002 Apr;5(4):376-81.

Callosotomy patients exhibit temporal uncoupling during continuous bimanual movements.

Author information

1
University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, California 94720, USA.

Abstract

Rhythmic bimanual movements are highly constrained in the temporal domain, with the gestures of the two hands tightly synchronized. Previous studies have implicated a subcortical locus for temporal coupling based on the observation that these constraints persist in callosotomy patients. We now report that such coupling is restricted to movements entailing a discrete event (such as a movement onset). Three callosotomy patients exhibited a striking lack of temporal coupling during continuous movements, with the two hands oscillating at non-identical frequencies. We propose a subcortical locus of temporal coupling for movements involving discrete events. In contrast, synchronization between the hands during continuous movements depends on interhemispheric transmission across the corpus callosum.

PMID:
11914724
DOI:
10.1038/nn822
[Indexed for MEDLINE]

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