Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Geriatr Med. 2002 Feb;18(1):103-20, vii.

The aged epidermal permeability barrier: basis for functional abnormalities.

Author information

1
Department of Dermatology, University of California, San Francisco, USA. eliaspm@itsa.ucsf.edu

Abstract

Aged epidermis develops an abnormality in permeability barrier homeostasis, which is accentuated further in photoaged skin. The biochemical basis is a global reduction in stratum corneum lipids and profound abnormality in cholesterol synthesis. Various cytokine/growth factor signaling pathways are abnormal in aged skin, particularly in the interleukin-1 family. Barrier repair therapy can be effective in restoring normal function if a cholesterol-dominant mixture of the three key physiologic lipids, including ceramides and free fatty acids, is emphasized.

PMID:
11913735
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center