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Nat Rev Immunol. 2002 Mar;2(3):175-84.

Chemokines: agents for the immunotherapy of cancer?

Author information

1
Departments of Dermatology and Radiation Oncology, Heinrich-Heine-University, D-40225 Düsseldorf, Germany. Bernhard.Homey@rz.uni-duesseldorf.de

Abstract

Chemokines, a superfamily of small cytokine-like molecules, regulate leukocyte transport in the body. In recent years, we have witnessed the transition of immunotherapeutic strategies from the laboratory to the bedside. Here, we review the role of chemokines in tumour biology and the development of the host's anti-tumour defence. We summarize the current knowledge of chemokine-receptor expression by relevant cellular components of the immune system and the role of their ligands in the organization of the antitumour immune response. Finally, we discuss recent findings which indicate that chemokines have therapeutic potential as adjuvants or treatments in antitumour immunotherapy, as well as remaining questions and perspectives for translating experimental evidence into clinical practice.

PMID:
11913068
DOI:
10.1038/nri748
[Indexed for MEDLINE]

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