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FEBS Lett. 2002 Feb 20;513(1):129-34.

Protein domain analysis in the era of complete genomes.

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EMBL, Meyerhofstrasse 1, Heidelberg, Germany.


Domains present one of the most useful levels at which to understand protein function, and domain family-based analysis has had a profound impact on the study of individual proteins. Protein domain discovery has been progressing steadily over the past 30 years. What are the realistically achievable goals of sequence-based domain analysis, and how far off are they for the sequences encoded in eukaryotic genomes? Here we address some of the issues involved in better coverage of sequence-based domain annotation, and the integration of these results within the wider context of genomes, structures and function.

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