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J Chem Inf Comput Sci. 2002 Mar-Apr;42(2):405-7.

A versatile structural domain analysis server using profile weight matrices.

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  • 1EMBL, Postfach 102209, D-69012 Heidelberg, Germany.


The WEB tool "AnDom" assigns to a given protein sequence all experimentally determined structural domains contained within it, including multidomain and large proteins. The server uses profile specific matrices from custom generated multiple sequence alignments of all known SCOP domains (SCOP version 1.50). Prediction time is short allowing numerous applications for structural genomics including investigation of complex eucaryotic protein families. The WWW server is at, and profiles can be downloaded at schmidt/AnDom.

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