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Nat Rev Immunol. 2002 Feb;2(2):96-105.

Lipid rafts and B-cell activation.

Author information

  • 1National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Immunogenetics, Twinbrook II, 12441 Parklawn Drive, Room 200B, MSC 8180, Rockville, Maryland 20852, USA. spierce@nih.gov

Abstract

The B-cell antigen receptor acts during B-cell activation both to initiate signalling cascades and to transport antigen into the cell for subsequent processing and presentation. Recent evidence indicates that membrane microdomains, termed lipid rafts, have a role in B-cell activation as platforms for B-cell receptor (BCR) signalling and might also act in antigen trafficking. Lipid rafts might facilitate the regulation of the BCR during B-cell development by B-cell co-receptors, and during viral infection. So, lipid rafts seem to be an important new piece of the B-cell signalling puzzle.

PMID:
11910900
DOI:
10.1038/nri726
[PubMed - indexed for MEDLINE]
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