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Nat Rev Immunol. 2002 Feb;2(2):127-32.

Redefinition of lymphoid progenitors.

Author information

1
Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. katsura@frontier.kyoto-u.ac.jp

Abstract

Similarities between T and B lymphocytes might have led to the idea that these functionally distinct cells develop from a common lymphoid progenitor. However, investigations with a new clonal assay which allows for T-, B- and myeloid-lineage development indicate that commitment to T-cell and B-cell lineages occurs instead through myeloid/T and myeloid/B bipotential stages, respectively. These findings provide an opportunity to reconsider the ontogeny and phylogeny of T- and B-cell development.

PMID:
11910894
DOI:
10.1038/nri721
[Indexed for MEDLINE]

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