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Alcohol Res Health. 2001;25(4):282-7.

Alcohol and the male reproductive system.

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Department of Medicine, Department of Molecular and Cellular Biochemistry, Division of Research on Drugs of Abuse, Loyola University Stritch School of Medicine, Maywood, Illinois, USA.


Alcohol use affects all three parts of the hypothalamic-pituitary-gonadal (HPG) axis, a system of endocrine glands and hormones involved in male reproduction. Alcohol use is associated with low testosterone and altered levels of additional reproductive hormones. Researchers are investigating several potential mechanisms for alcohol's damage. These mechanisms are related to alcohol metabolism, alcohol-related cell damage, and other hormonal reactions associated with alcohol consumption. Chronic alcohol use in male rats also has been shown to affect their reproductive ability and the health of their offspring.

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