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Bioorg Med Chem Lett. 2002 Apr 8;12(7):1103-7.

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes.

Author information

1
COR Therapeutics, Inc., Department of Medicinal Chemistry, South San Francisco, CA 94080, USA.

Abstract

The synthesis and biological activity of analogues containing spiro piperidinylpyridine and pyrrolidinylpyridine templates are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spiro structures as central template for nonpeptide RGD mimics.

PMID:
11909727
DOI:
10.1016/s0960-894x(02)00095-1
[Indexed for MEDLINE]

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