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Curr Biol. 2002 Mar 19;12(6):R200-2.

Notch cleavage: Nicastrin helps Presenilin make the final cut.

Author information

1
University of California, Department of Molecular and Cell Biology, Berkeley 94720-3200, USA. lai@fruitfly.bdgp.berkeley.edu

Abstract

Presenilin is thought to be the proteolytic component of gamma-secretase, responsible for the intramembranous cleavage of substrates that include the activated Notch receptor. Recent studies have identified the novel protein Nicastrin as another essential component of the Presenilin/gamma-secretase complex.

PMID:
11909545
DOI:
10.1016/s0960-9822(02)00749-2
[Indexed for MEDLINE]
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