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Cell. 2002 Feb 22;108(4):545-56.

Gene-specific regulation by general translation factors.

Author information

1
Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. t.dever@box-t.nih.gov

Abstract

Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, processing, or export. Recent studies have enhanced our understanding of the translation initiation process and helped elucidate how modifications of the general translational machinery regulate gene-specific protein production.

PMID:
11909525
DOI:
10.1016/s0092-8674(02)00642-6
[Indexed for MEDLINE]
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