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Cell. 2002 Feb 22;108(4):523-31.

A conserved mRNA export machinery coupled to pre-mRNA splicing.

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Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.


Recent advances have led to a new understanding of how mRNAs are exported from the nucleus to the cytoplasm. This process requires a heterodimeric mRNA export receptor that is part of an elaborate machinery conserved from yeast to humans. Export of mRNAs is coupled to upstream steps in gene expression, such as pre-mRNA splicing, and to downstream events, including nonsense-mediated decay.

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