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Anticancer Res. 2001 Nov-Dec;21(6B):4243-52.

Hepatocyte growth factor expression in human cancer and therapy with specific inhibitors.

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Laboratory of Tumor Metastasis and Angiogenesis, Van Andel Research Institute, Grand Rapids, MI 49503, USA.


Hepatocyte growth factor/Scatter Factor (HGF/SF) mediated stimulation of the Met receptor tyrosine kinase results in pleiotropic cellular effects including proliferation, morphogenesis, motility and invasion. In vivo, HGF/SF-Met activation has been shown to participate in tumorigenesis, angiogenesis and metastasis. Coupled with accumulating evidence that aberrant HGF/SF-Met expression is frequently observed in a variety of human tumors, often in association with progressive disease, these data present HGF/SF-Met as an attractive target for therapeutic intervention in human cancer. In this review, we will present the most compelling evidence suggesting a key role for HGF/SF-Met signaling in tumorigenesis, and discuss several possible therapeutic strategies.

[Indexed for MEDLINE]

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