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J AAPOS. 2002 Feb;6(1):26-32.

Retinoblastoma in older children.

Author information

1
King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Abstract

PURPOSE:

Retinoblastoma (RB) is known to present with atypical signs and symptoms in older patients. Our article reviews the clinical and histopathological features of RB encountered in children older than 5 years of age.

METHODS:

A total of 337 consecutive patients with RB were reviewed. Eighteen (5.3%; 10 males, 8 females) who presented after the age of 5 were selected for further analysis of clinical data and histopathological material in this retrospective, non-comparative case series.

RESULTS:

The age range was from 5 to 12 years (mean age 6.4). Unilateral disease was seen in 14 children, bilateral disease in 4 children. Eleven children were the product of consanguineous marriages. Seven patients had leukocoria; the others presented with signs of uveitis, cellulitis, and/or trauma. Three patients had flat, plaque-like lesions on histopathologic evaluation.

CONCLUSIONS:

Clinical and histopathologic features were atypical in 47% and 21% respectively in the retinoblastoma patients who presented after the age of 5 years.

PMID:
11907476
DOI:
10.1067/mpa.2002.120643
[Indexed for MEDLINE]

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