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Vaccine. 2002 Mar 15;20(13-14):1823-30.

Immune response to synthetic peptides of dengue prM protein.

Author information

1
Virology Department, "Pedro Kouri" Tropical Medicine Institute, Autopista Novia del Mediodia, km 6, P.O. Box Marianao 13, Havana, Cuba. svazquez@ipk.sld.cu

Abstract

The immunological activities of five synthetic peptides of the prM protein of dengue-2 (DEN-2) virus containing B cell epitopes were evaluated in BALB/c mice. Two peptides elicited neutralizing antibodies against all four DEN serotypes. Virus-specific proliferative responses were demonstrated in mice immunized with four of the five peptides, demonstrating the presence of T cell epitopes. Mice immunized with three of the five peptides conjugated with bovine albumin showed statistically significant levels (P<0.05) of protection when challenged with DEN-2 virus. These results could constitute the basis for the establishment of the role of DEN virus pre and M antigens in the development of anti-flaviviral vaccines.

PMID:
11906771
DOI:
10.1016/s0264-410x(01)00515-1
[Indexed for MEDLINE]

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