Send to

Choose Destination
Vaccine. 2002 Mar 15;20(13-14):1823-30.

Immune response to synthetic peptides of dengue prM protein.

Author information

Virology Department, "Pedro Kouri" Tropical Medicine Institute, Autopista Novia del Mediodia, km 6, P.O. Box Marianao 13, Havana, Cuba.


The immunological activities of five synthetic peptides of the prM protein of dengue-2 (DEN-2) virus containing B cell epitopes were evaluated in BALB/c mice. Two peptides elicited neutralizing antibodies against all four DEN serotypes. Virus-specific proliferative responses were demonstrated in mice immunized with four of the five peptides, demonstrating the presence of T cell epitopes. Mice immunized with three of the five peptides conjugated with bovine albumin showed statistically significant levels (P<0.05) of protection when challenged with DEN-2 virus. These results could constitute the basis for the establishment of the role of DEN virus pre and M antigens in the development of anti-flaviviral vaccines.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center