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J Med Chem. 2002 Mar 28;45(7):1395-8.

Design, synthesis, and evaluation of opioid analogues with non-peptidic beta-turn scaffold: enkephalin and endomorphin mimetics.

Abstract

We have identified a mu-selective opioid receptor agonist without a cationic amino group in the molecule from libraries of bicyclic beta-turn peptidomimetics. The biologically active conformation of the lead is proposed to mimic an endomorphin type III 4 --> 1 beta-turn conformation.

PMID:
11906279
DOI:
10.1021/jm0155897
[Indexed for MEDLINE]

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