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Nat Rev Immunol. 2002 Jan;2(1):46-53.

Transforming growth factor-beta in T-cell biology.

Author information

1
Biogen, Inc, Cambridge, Massachusetts 02139, USA.

Abstract

Strict control of T-cell homeostasis is required to permit normal immune responses and prevent undesirable self-targeted responses. Transforming growth factor-beta (TGF-beta) has been shown to have an essential role in that regulation. Owing to its broad expression, and inhibitory effects on multiple cell types of the immune system, TGF-beta regulation is complex. Through advances in cell-specific targeting of TGF-beta signalling in vivo, the role of TGF-beta in T-cell regulation has become clearer. Recent in vitro studies provide a better understanding of how TGF-beta regulates T-cell homeostasis, through multiple mechanisms involving numerous cell types.

PMID:
11905837
DOI:
10.1038/nri704
[Indexed for MEDLINE]

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