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Nat Rev Immunol. 2001 Dec;1(3):220-8.

T-cell regulation by CD28 and CTLA-4.

Author information

1
Department of Medicine, Section of Rheumatology and Committee in Immunology, Chicago, Illinois 60637, USA. malegre@midway.uchicago.edu

Abstract

Activation of T lymphocytes is thought to require at least two signals, one delivered by the T-cell receptor complex after antigen recognition, and one provided on engagement of co-stimulatory receptors, such as CD28. Recent studies are providing clues as to the specific signalling roles of co-stimulatory receptors. Furthermore, superimposition of inhibitory signals, such as those delivered by cytotoxic T-lymphocyte antigen 4 (CTLA-4), leads to a complex network of positive and negative co-stimulatory signals, the integration of which modulates immune responses.

PMID:
11905831
DOI:
10.1038/35105024
[Indexed for MEDLINE]

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