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Nat Rev Immunol. 2001 Nov;1(2):147-53.

From T to B and back again: positive feedback in systemic autoimmune disease.

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Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8035, USA.


Systemic lupus erythematosus, a prototypical systemic autoimmune disease, is the result of a series of interactions within the immune system that ultimately lead to the loss of self-tolerance to nuclear autoantigens. Here, we present an integrated model that explains how self-tolerance is initially lost and how the loss of tolerance is then amplified and maintained as a chronic autoimmune state. Key to this model are the self-reinforcing interactions of T and B cells, which we suggest lead to perpetuation of autoimmunity as well as its spread to multiple autoantigen targets.

[Indexed for MEDLINE]

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