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Nat Rev Cancer. 2001 Nov;1(2):99-108.

Pharmacogenetics and cancer therapy.

Author information

1
Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. mary.relling@stjude.org

Abstract

Pharmacogenetics is the study of how genetic variations affect drug response. These variations can affect a patient's response to cancer drugs, for which there is usually a fine line between a dosage that has a therapeutic effect and one that produces toxicity. Gaining better insight into the genetic elements of both the patient and the tumour that affect drug efficacy will eventually allow for individualized dosage determination and fewer adverse effects.

PMID:
11905809
DOI:
10.1038/35101056
[Indexed for MEDLINE]
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