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Nat Rev Cancer. 2001 Nov;1(2):162-8. doi: 10.1038/35101096.

Actin' up: RhoB in cancer and apoptosis.

Author information

1
The DuPont Pharmaceuticals Company, Glenolden Laboratory, Pennsylvania 19004, USA. george.c.prendergast@dupontpharma.com

Abstract

RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required for signalling apoptosis in transformed cells that are exposed to farnesyltransferase inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is dispensable for normal cell physiology, but that it has a suppressor or negative modifier function in stress-associated processes, including cancer.

PMID:
11905808
DOI:
10.1038/35101096
[Indexed for MEDLINE]

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