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Nat Rev Cancer. 2001 Nov;1(2):142-50.

How melanoma cells evade trail-induced apoptosis.

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1
Immunology and Oncology Unit, Newcastle, New South Wales, Australia. Peter.Hersey@newcastle.edu.au

Abstract

At the doses used clinically, chemotherapy is believed to kill melanoma by a final common 'mitochondrial' pathway that leads to apoptosis. Similarly, several natural defence mechanisms kill melanoma by the same pathways. A corollary to the latter is that survival of melanoma in the host is due to the development of anti-apoptotic mechanisms in melanoma cells. What are these mechanisms? And how might we bypass them to improve the treatment of melanoma?

PMID:
11905805
DOI:
10.1038/35101078
[Indexed for MEDLINE]
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