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Yakugaku Zasshi. 2002 Mar;122(3):219-36.

[From new molecular science to new supramolecular science with macrocyclic polyamines].

[Article in Japanese]

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Department of Medicinal Chemistry, Faculty of Medicine, Hiroshima University, Kasumi, Minami-ku, 1-2-3, Hiroshima 734-8551, Japan.


Exploitation of saturated macrocyclic polyamines has led to the discovery of numerous novel functions and new molecules such as 1) unique proton sponge properties; 2) uptake of biological polyanions; 3) peptide-like metal uptake properties; 4) stabilization of unusual oxidation states of metal ions (e.g., CuIII, NiIII); 5) novel uptake and activation of O2 by new NiII-macrocyclic complexes; 6) a new synthetic pathway to functionalize macrocyclic polyamines; 7) the first gold(III) complex that is a new candidate for gold-plating agents; 8) intrinsic zinc(II) properties pertinent to zinc enzymes; 9) selective recognition of thymine by ZnII complexes; and 10) new cage supermolecules. These newly discovered molecules and properties have opened up a new field of supramolecular science.

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