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FEBS Lett. 2002 Mar 6;514(1):49-54.

Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e).

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Department of Biological Chemistry, School of Medicine, University of California, Davis, CA 95616, USA.


Several components of translation, e.g. eIF4E and PKR, are implicated in cancer. The e-subunit (p48) of mammalian initiation factor 3 is encoded by the Int6 gene, a common site for integration of the mouse mammary tumor virus genome, leading to the production of a truncated eukaryotic initiation factor-3e (eIF3e). Stable expression of a truncated eIF3e in NIH 3T3 cells causes malignant transformation by four criteria: foci formation; anchorage independent growth; accelerated growth; and lack of contact inhibition. Stable expression of full-length eIF3e does not cause transformation. The truncated eIF3e also inhibits the onset of apoptosis caused by serum starvation.

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