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Epilepsia. 2002 Feb;43(2):201-4.

Lidocaine-dependent early infantile status epilepticus with highly suppressed EEG.

Author information

1
Department of Pediatrics, Akita University School of Medicine, Japan. sawaishi@ped.med.akita-u.ac.jp

Abstract

We report an early infantile patient characterized by intractable hyponatremia, progressive megalencephaly, and epileptic seizures with an EEG pattern that alternated between interictal low-voltage background and ictal burst activity. Repeatedly all the abnormal findings improved in a lidocaine-dependent manner. Given the pharmacologic mechanisms of lidocaine as a sodium channel blocker, we speculate that our patient had a sodium channel dysfunction.

PMID:
11903470
[Indexed for MEDLINE]
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