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Acta Neurol Scand. 2001 Dec;104(6):385-8.

Diffusion-weighted MR findings of central pontine and extrapontine myelinolysis.

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Department of Neurology, Seoul National University Hospital, Neuroscience Research Institute, SNUMRC, South Korea.


Diffusion-weighted MR (DWI) can detect changes in water diffusion associated with cellular dysfunction, which enables the differentiation of cytotoxic edema from vasogenic edema. In this study on DWI findings in central pontine (CPM) and extrapontine myelinolysis (EPM), DWI showed high signal intensities in the bilateral pons, midbrain, and genu of the corpus callosum. The corresponding apparent diffusion coefficient values were rather low. This suggests that cytotoxic edema does in fact exist in CPM and EPM and that DWI can be useful in the rapid diagnosis and prediction of the various types of edema occurring in active demyelinating diseases.

[Indexed for MEDLINE]

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