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Farmaco. 2002 Jan;57(1):39-44.

Antimicrobial activity of 5-arylidene aromatic derivatives of hydantoin. Part 2.

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Department of Chemical Technology of Drugs, Jagiellonian University Medical College, Kraków, Poland.


Various 5-chloroarylidene-2-amino substituted derivatives of imidazoline-4-one were synthesized and evaluated for their activity in vitro against Mycobacterium tuberculosis and other type strains of bacteria and fungi. 2-Chloro- and 2,4-dichlorobenzylidene substituted hydantoins exhibited antimycobacterial effect. The most potent compounds 3i, 3j, 3o, 3q and 3s were classified for further tests. The antimitotic effect of the investigated hydantoins was also examined.

[Indexed for MEDLINE]

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