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Nat Rev Cancer. 2002 Jan;2(1):28-37.

Helicobacter pylori and gastrointestinal tract adenocarcinomas.

Author information

1
Division of Gastroenterology, Vanderbilt University School of Medicine, Medical Center North, Nashville, Tennessee 37232-2279, USA. richard.peek@mcmail.vanderbilt.edu

Abstract

Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain and host genotypes probably influence the risk of carcinogenesis by differentially affecting host inflammatory responses and epithelial-cell physiology. Understanding the host-microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.

PMID:
11902583
DOI:
10.1038/nrc703
[Indexed for MEDLINE]
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