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Nat Rev Cancer. 2001 Dec;1(3):203-13.

Cell senescence and cancer.

Author information

1
Department of Biochemistry, University College London, UK.

Abstract

Historically, the senescent state has been associated with, and was named after, the cell-cycle arrest that occurs after cells have undergone an intrinsically defined number of divisions in vitro. More recently, however, it has been shown that extrinsic factors, including those encountered in normal tissue-culture environments, can prematurely induce an indistinguishable senescent phenotype. In this review, we discuss the pathways of cell senescence, the mechanisms involved and the role that these pathways have in regulating the initiation and progression of cancer.

PMID:
11902575
DOI:
10.1038/35106045
[Indexed for MEDLINE]
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