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Curr Med Res Opin. 2001;17(3):223-9.

Focus on clozapine.

Author information

1
Hollins Park Hospital, Warrington, Cheshire, UK.

Abstract

Clozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic effects are probably mediated by dopaminergic and serotonergic activity. Although it appears to be the most effective antipsychotic drug for treatment-resistant schizophrenia, its general use is limited because of the risk of agranulocytosis.

PMID:
11900316
DOI:
10.1185/0300799039117069
[Indexed for MEDLINE]

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