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Nat Rev Cancer. 2001 Oct;1(1):46-54.

Putting tumours in context.

Author information

1
Division of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California 99720, USA. mjbissell@lbl.gov

Abstract

The interactions between cancer cells and their micro- and macroenvironment create a context that promotes tumour growth and protects it from immune attack. The functional association of cancer cells with their surrounding tissues forms a new 'organ' that changes as malignancy progresses. Investigation of this process might provide new insights into the mechanisms of tumorigenesis and could also lead to new therapeutic targets.

PMID:
11900251
PMCID:
PMC2975572
DOI:
10.1038/35094059
[Indexed for MEDLINE]
Free PMC Article
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