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Nat Rev Cancer. 2001 Oct;1(1):11-21.

Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.

Author information

1
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-2279, USA.

Abstract

Population-based studies have established that long-term intake of non-steroidal anti-inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of cyclooxygenase (COX), reduces the relative risk for developing colorectal cancer. These studies led to the identification of a molecular target, COX-2, that is involved in tumour promotion during colorectal cancer progression. Recent studies in humans indicate that therapy with specific COX-2 inhibitors might be an effective approach to colorectal cancer prevention and treatment.

PMID:
11900248
DOI:
10.1038/35094017
[Indexed for MEDLINE]

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