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Zh Vyssh Nerv Deiat Im I P Pavlova. 2002 Jan-Feb;52(1):97-103.

[Chronic stress and forming of psychoemotional state during prepubertal period in rats].

[Article in Russian]

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Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russia.


Immediate and long-lasting effects of chronic stress during prepubertal period (21-32 postnatal days) on anxiety- and depression-related behavior were studied in Wistar and ISIAH (inherited stress-induced arterial hypertension) rats. Significant interstrain differences were found. Both juvenile and adult ISIAH rats were less anxious in the elevated plus-maze and less depressed in the forced swimming test. Immediate effects of the prepubertal stress were similar in both rat strains and depended on the type of stimulation. Long-lasting effects were genotype-dependent. Chronic prepubertal handling exerted an anxiolytic effect in young ISIAH and Wistar rats and adult Wistar rats. Immediate anxiogenic effect of prepubertal unpredictable stress was preserved only in adult ISIAH rats. Depression-related behavior was intensified by the unpredictable stress in young animals, whereas the long-lasting effect was observed only in adult hypertensive rats.

[Indexed for MEDLINE]

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